90210: One of the main characters, Silver, is diagnosed with Bipolar Disorder.
Friday Night Lights: After exhibiting key characteristics of bi-polar disorder - hypersexuality followed by euphoria followed by depression - "Smash" Williams's girlfriend Waverly Grady admits that she hasn't been taking her medications for a "mood disorder", which is eventually revealed indeed to be bi-polar. This causes her and Smash's relationship lots of trial, though Smash is willing to put in the effort.
ER: Sally Field, as Maggie Wyczenski, endures major manic and depressive episodes, and must also face the implications of bipolar being inherited by other family members. The role earned her an Emmy.